18 F-FDG PET imaging of postoperative and postradiotherapeutic intracranial glioma compared with CT, MRI in 16 cases / 中华核医学杂志

ABSTRACT

Objective　To discuss the clinical value of 18　F-FDG PET imaging in postoperative and postradiotherapeutic intracranial glioma during follow up study. Methods　18F-FDG PET imaging in 16 cases of postoperative and postradiotherapeutic intracranial glioma was compared with CT and/or MRI. Results　Contrast CT or MRI showed prominent irregular circular or nodular enhancement in 14 of 16 cases (64%),can not distinguished from postopertative changes, radioinjury, tumor residue or recurrence.Among them, 9 cases showed tumor residue or recurrence based on significantly increased FDG uptake, 5 were confirmed by pathologic study. The other 5 cases of cerebral necrosis and 2 cases with postoperative cerebral malacia demonstrated FDG uptake defects. Conclusions　18F-FDG PET imaging has significant dominance in characterizing lesions for differentiating residue or recurrent disease from radioinjury in intracranial glioma. Combined with CT and MRI can provide both anatomical and functional informations.