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Uptake volume index of 18F-FDG PET/CT for the prediction of prognosis in nasopharyngeal carcinoma / 中华核医学杂志
Chinese Journal of Nuclear Medicine ; (6): 151-154, 2010.
Article in Chinese | WPRIM | ID: wpr-642603
ABSTRACT
Objective To evaluate the prognostic value of serial 18F-fluorodeexyglucose (FDG) PET/CT in patients with nasopharyngeal carcinoma (NPC).Methods Thirty-seven NPC patients who had 18F-FDG PET/CT scan before and after external beam intensity-modulated radiotherapy, were studied retrospectively.All patients were followed for five years.Correlation analysis between metabolic tumor volume (MTV)/uptake volume index (UVI) and survival was performed by Kaplan-Meier analysis, Log-rank test and multivariate Cox model.Results The 5-year overall survival (OS) and disease-free survival (DFS) rates were 70.3% (26/37) and 62.2% ( 23/37 ), respectively.Patients with a lower MTV (MTV<30 cm3) had significantly higher 5-year OS ( 82.6% ( 19/23 ) ) and DFS (73.9% ( 17/23 )) rates than those with a higher MTV (OS50.0% (7/14),x2 =5.28, P<0.05; DFS42.9% (6/14),x2 =4.84, P<0.05).Patients with a lower UV1 (UVI<150) had significantly higher 5-year OS( 87.5%( 21/24 )) and DFS (79.2% (19/24)) rates than those with a higher UVI (OS38.5% (5/13),x2 =10.72, P<0.01;DFS30.8% (4/13), x2 =11.04, P<0.01).Multivariate analysis showed that UVI and metabolic response (MR) were independent predictors of DFS.Conclusions Tumor volume parameters, UVI and MR, are independent prognostic factors for patients with NPC.Patients with a high UVI may benefit from more aggressive treatment.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Nuclear Medicine Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Chinese Journal of Nuclear Medicine Year: 2010 Type: Article