Detection of Epstein-Barr Virus DNA in Oropharynx by Polymerase Chain Reaction / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 73-76, 1998.
Article
in Korean
| WPRIM
| ID: wpr-643604
ABSTRACT
BACKGROUND AND OBJECTIVES:
The Epstein-Barr virus (EBV) is a human herpes virus which causes infectious mononucleosis and is associated with such human cancers as Burkitt's Lymphoma, Hodgkin's disease, non-Hodgkin's disease, and nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head & neck tumors is not fully elucidated. This study analyzed the detection rate of Epstein-Barr virus (EBV) in the throat washing samples from pateints with head and neck tumors and non-malignant diseases, as well as from normal subjects. MATERIALS &METHODS:
The throat washing samples were collected from 49 patients of head & neck tumors, 52 patients of non-malignant diseases (pharyngitis and tonsillitis) and 24 normal subjects. The EBV DNA was detected by using the EBV (BNRF1)-specific primers & Polymerase Chain Reaction (PCR).RESULT:
The EBV DNA was detected in 25 (51%) of the 49 throat washing samples from patients with tumors, as well as 3 (60%) of 5 samples from patients with nasopharyngeal carcinoma, and 22 (50%) of 44 samples from patients with head and neck tumors. The throat wasing samples from 52 patients with non-malignant diseases and 24 samples from healthy subjects were also examined. EBV was detected in 17 (32.7%) of 52 patients with non-malignant diseases and 3 (12.5%) of 24 samples from healthy subjects.CONCLUSION:
These data indicate that the EBV may be related to non-malignant diseases and head and neck tumor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oropharynx
/
Pharynx
/
DNA
/
Hodgkin Disease
/
Polymerase Chain Reaction
/
Burkitt Lymphoma
/
Herpesvirus 4, Human
/
Head
/
Infectious Mononucleosis
/
Neck
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
1998
Type:
Article
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