The study of nerve regeneration with infiltration of normal saline and nerve growth factor after vein graft to the resected sciatic nerve / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 17-24, 2001.
Article
in Korean
| WPRIM
| ID: wpr-643656
ABSTRACT
PURPOSE:
To compare the effect of nerve regeneration with infiltration of normal saline and nerve growth factor after vein graft to the resected sciatic nerve of rat. MATERIALS ANDMETHODS:
Eighty Sprague-Dawley rats were divided into five experimental groups orthotopic nerve graft as control group, inside-in vein graft with normal saline infiltration, inside-out vein graft with normal saline infiltration, inside-in vein graft with nerve growth factor infiltration and inside-out vein graft with nerve growth factor infiltration group. Animals of each group were sacrificed after electromyography at 2, 4, 8 and 12 weeks after operation. Also the light microscopy and transmission electron microscopy were performed to observe histologic change of grafted sites.RESULTS:
This study demonstrates that autogenous vein graft serves as a conduit for nerve regeneration, and inside-out vein graft technique and nerve growth factor induce faster and more numerous axonal regeneration and earlier recovery of muscle power.CONCLUSION:
Inside-out vein graft with nerve growth factor infiltration is supposed to be a promising technique to take the place of autogenous nerve graft.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Sciatic Nerve
/
Axons
/
Veins
/
Rats, Sprague-Dawley
/
Transplants
/
Nerve Growth Factor
/
Microscopy, Electron, Transmission
/
Electromyography
/
Microscopy
Limits:
Animals
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2001
Type:
Article
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