The Changes of Aqueous Vasopermeability Factors After Intravitreal Triamcinolone Injection for Branch Retinal Vein Occlusion
Journal of the Korean Ophthalmological Society
;
: 1765-1770, 2008.
Article
in Korean
| WPRIM
| ID: wpr-64366
ABSTRACT
PURPOSE:
To investigate the changes of aqueous vascular endothelial growth factor (VEGF) and interleukin (IL)-6 in patients with acute macular edema secondary to recent-onset branch retinal vein occlusion (BRVO) after a single intravitreal injection of triamcinolone acetonide (IVTA)METHODS:
Aqueous and plasma levels of VEGF and IL-6 were measured by ELISA in ten controls and thirty patients at the time of IVTA and 3 months afterward. We compared the aqueous levels of VEGF and IL-6 and the clinical course between responders and non-responders.RESULTS:
The aqueous levels of VEGF and IL-6 were significantly higher in non-responders than in responders at baseline measurements (495+/-259 pg/ml vs. 223+/-110 pg/ml, P<.001; 36+/-32 pg/ml vs. 16+/-19 pg/ml, P=.037, respectively). The aqueous levels of VEGF were still higher in non-responders (303+/-75 pg/ml) 3 months after IVTA, while the aqueous levels of VEGF in responders returned to normal (77+/-23 pg/ml, P<.001). The aqueous levels of IL-6 normalized in all patients 3 months after IVTA. In non-responders, central foveal thickness was significantly higher, and foveal ischemia and a wide non-perfused area were more common.CONCLUSIONS:
Non-IL6-dependent VEGF may contribute to persistent or recurrent ischemic macular edema associated with BRVO after IVTA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Retinal Vein
/
Retinaldehyde
/
Retinal Vein Occlusion
/
Enzyme-Linked Immunosorbent Assay
/
Triamcinolone
/
Triamcinolone Acetonide
/
Macular Edema
/
Interleukins
/
Interleukin-6
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2008
Type:
Article
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