Effect of Salicylate on DPOAEs and ABRs in Guinea Pigs / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 646-650, 2002.
Article
in Korean
| WPRIM
| ID: wpr-643835
ABSTRACT
BACKGROUND AND OBJECTIVES:
Salicylates are well-known for producing reversible hearing loss and tinnitus. However, the site and mechanism of salicylate ototoxicity remain unresolved. Recent experiments suggest that reversible biochemical and/or metabolic changes in the cochlea seem to play an important role in salicylate ototoxicity. The purpose of this study was to investigate the site of lesion in salicylate ototoxicity by audiometric study. MATERIALS ANDMETHOD:
ABRs and DPOAEs were observed after intraperitoneal injection of 500 mg/kg of sodium salicylate on 24 ears of guinea pigs.RESULTS:
Salicylate produced a significant increase in the ABR threshold. Maximum changes were obtained in 4 hours, and recovered to the baseline in 24 hours after salicylate administration. The pattern of hearing loss shown by latency-intensity function was compatible with the cochlear type of hearing loss. The echo amplitude on DPOAEs at f2=2002, 4004 Hz was significantly decreased at 2, 4, 6, 8 hours, and returned to the baseline in 24 hours after salicylate administration. The time course of the change of DPOAEs was parallel with that of ABRs.CONCLUSION:
These results reflect that the cochlear outer hair cells may be the main site of lesion in salicylate ototoxicity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Audiometry
/
Tinnitus
/
Salicylates
/
Sodium Salicylate
/
Guinea
/
Cochlea
/
Ear
/
Guinea Pigs
/
Hair
/
Hearing Loss
Limits:
Animals
Country/Region as subject:
Africa
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2002
Type:
Article
Similar
MEDLINE
...
LILACS
LIS