Expression and Clinical Significance of Heparanasein Osteosarcoma / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 43-51, 2006.
Article
in Korean
| WPRIM
| ID: wpr-644198
ABSTRACT
PURPOSE:
This study examined the expression of heparanase in osteosarcomas and evaluated its prognostic value. MATERIALS ANDMETHODS:
The immunohistochemical expression of heparanase from 51 osteosarcoma tissues was examined, and the correlations between the heparanase expression level and the clinicopathological factors were evaluated.RESULTS:
Heparanase over-expression was observed in 37 tissue samples. There was a correlation between the heparanase expression level and a poor chemotherapeutic response, metastasis and poor survival rate. Multivariate analyses revealed that heparanase over-expression was a significant independent risk factor for a distant metastasis of an osteosarcoma. Among the 46 patients who underwent an adequate wide resection, there was a correlation between the heparanase expression level and recurrence. The 5-year survival rate was 83.8% for patients with heparanase negative tumors, and 46.9% for those with heparanase over-expression. Multivariate analysis using the Cox regression model revealed the heparanase expression level to be an independent prognostic indicator.CONCLUSION:
These results indicate that heparanase expression might play an important role in local recurrence and metastasis, and might be a biological marker of the prognostic significance in osteosarcoma patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Recurrence
/
Immunohistochemistry
/
Biomarkers
/
Osteosarcoma
/
Multivariate Analysis
/
Survival Rate
/
Risk Factors
/
Neoplasm Metastasis
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2006
Type:
Article
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