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Immunohistochemical Study on Platelet-Derived Growth Factor alpha-Receptor (PDGF-alphaR) in the Canine Cerebellum During Postnatal Development / 대한해부학회지
Korean Journal of Anatomy ; : 495-501, 2001.
Article in Ko | WPRIM | ID: wpr-644254
Responsible library: WPRO
ABSTRACT
The biological activities of PDGF include stimulation of mitogenesis, chemotaxis, and differentiation. In nervous system, previous studies have shown that PDGF has an important role in the generation of cells of a glial lineage. However, several studies demonstrated that mature and immature neurons could also synthesize PDGF-alphaR. In the present study, to analyze the distributional pattern of PDGF-alphaR during postnatal development of the canine cerebellum, we used immunohistochemistry. We found that neurons of cerebellum, including Purkinje cells and granules cells, showed immunoreactivity to PDGF-alphaR (IRPDGF-alphaR) as early as postnatal day 0. Whereas IRPDGF-alphaR immunoreactivity in the Purkinje cells were maintained at all postnatal ages. Our data support that PDGF may have the important roles during development and survival of neurons.
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Full text: 1 Index: WPRIM Main subject: Purkinje Cells / Platelet-Derived Growth Factor / Immunohistochemistry / Cerebellum / Chemotaxis / Nervous System / Neurons Limits: Animals Language: Ko Journal: Korean Journal of Anatomy Year: 2001 Type: Article
Full text: 1 Index: WPRIM Main subject: Purkinje Cells / Platelet-Derived Growth Factor / Immunohistochemistry / Cerebellum / Chemotaxis / Nervous System / Neurons Limits: Animals Language: Ko Journal: Korean Journal of Anatomy Year: 2001 Type: Article