Expression of Human b-Defensin-1 mRNA in Human Nasal Mucosa / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 282-285, 2000.
Article
in Korean
| WPRIM
| ID: wpr-644287
ABSTRACT
BACKGROUND AND OBJECTIVES:
Antimicrobial peptides are cationic proteins that are found in a wide range of organisms. Recent reports suggest that human beta-defensin-1 (hBD-1), a prominent group of antimicrobial peptides, is an important component of the innate immune response, particularly at mucosal surfaces that are vulnerable to colonization by potential pathogens. Therefore, hBD-1 may participate in providing intrinsic nasal mucosal defense against microbial infections. The present study aimed to look for hBD-1 mRNA in apparently normal human nasal mucosa. MATERIALS ANDMETHODS:
The expression of hBD-1 mRNA was investigated in the inferior turbinate tissues using reverse transcription-polymerase chain reaction (RT-PCR) and in situ hybridization.RESULTS:
The expression of hBD-1 mRNA was detected in these tissues. By in situ hybridization, hBD-1 mRNA was predominantly localized in superficial epithelial cells and submucosal glandular epithelium.CONCLUSION:
These data suggest that nasal epithelia and submucosal glands may secrete hBD-1 and thus contribute to the mucosal defense of the nose.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peptides
/
Turbinates
/
RNA, Messenger
/
Nose
/
In Situ Hybridization
/
Colon
/
Epithelial Cells
/
Epithelium
/
Immunity, Innate
/
Nasal Mucosa
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2000
Type:
Article
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