Immunoglobulin E and Transcription Factor in Adenoid of Children with Allergy / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 594-598, 2009.
Article
in Korean
| WPRIM
| ID: wpr-644875
ABSTRACT
BACKGROUND AND OBJECTIVES:
Immunoglobulin E (IgE) production in adenoid has been debated and the role of adenoid in development of allergy remains largely unknown. To examine the production of local IgE in adenoid involved with IgE-mediated sensitization, we evaluated IgE production and the expression of the transcription factor B cell leukemia/lymphoma-6 (BCL-6) and B lymphocyte inducer of maturation program 1 (Blimp-1) in adenoids. SUBJECTS ANDMETHOD:
Ten children with allergic rhinitis (AR) and ten children without any history of AR were enrolled. Immunohistochemical studies of adenoid for IgE, BCL-6 and Blimp-1 were performed.RESULTS:
IgE was stained mainly in the germinal center and submucosal area and the stainingscores of antibody to IgE did not differ signigicantly between children with AR and control. BCL- 6 was mainly stained in mucosa and germinal center and Blimp-1 in mucosa. The scores of antibody to BCL-6 and Blimp-1 in children with AR and control did not show significant differences.CONCLUSION:
We found that allergic rhinitis was not involved in the production of IgE nor the expression of the transcription factor BCL-6 and Blimp-1 in adenoid
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Transcription Factors
/
Immunoglobulin E
/
Immunoglobulins
/
Lymphocytes
/
Adenoids
/
Rhinitis
/
Rhinitis, Allergic, Perennial
/
Germinal Center
/
Hypersensitivity
/
Mucous Membrane
Limits:
Child
/
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2009
Type:
Article
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