Prostaglandin E2 Receptors on Upper Respiratory Tract / 대한이비인후과학회지

ABSTRACT

Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). GPCRs responding to PGE2 consist of four subtypes namely E-prostanoid 1 (EP1), E-prostanoid 2 (EP2), E-prostanoid 3 (EP3), and E-prostanoid 4 (EP4) and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction pathway, tissue localization, and regulation of expression. This molecular and biochemical heterogeneity of PGE2 receptors leads to PGE2 being the most variable prostanoid. Studies on knockout mice deficient in each EP subtype and selective agonist and antagonist have defined PGE2 actions mediated by each subtype and identified the role each EP subtype plays in various physiological and pathophysiological responses. We summarize and review PGE2 receptor research.