Expression of Cyclooxygenase 1 and 2 in Laryngeal Squamous Cell Carcinoma / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 957-961, 2001.
Article
in Korean
| WPRIM
| ID: wpr-645035
ABSTRACT
BACKGROUND AND OBJECTIVES:
A large body of evidence from a variety of experimental systems suggests that cyclooxygenase-2 (COX-2) is important in carcinogenesis. This study was to determine whether cyclooxygenase-1 (COX-1) and COX-2 were overexpressed in laryngeal squamous cell carcinoma, and discuss the possible causal role of COX-2 in the laryngeal squamous cell carcinoma formation. MATERIALS ANDMETHODS:
Tissue samples from 21 pateints with laryngeal squamous cell carcinoma were analyzed by immunohistochemical staining.RESULTS:
There was an elevation of COX-2 expression in laryngeal squamous cell carcinoma. Normal buccal mucosa biopsies and normal laryngeal epitheliums adjacent to laryngeal cancer showed nondetectable or weak staining for COX-2 protein. There is no difference in the expression of COX -1 in the normal buccal mucosa, normal laryngeal mucosa and laryngeal squamous cell carcinoma.CONCLUSION:
There is an overexpression of COX-2, but not COX-1 in laryngeal squamous cell cancer. This may represent a causal role of COX-2 in the formation and proliferation of laryngeal squamous cell carcinoma. There may also be another role of selective COX-2 inhibition for treatment of laryngeal squamous cell carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Prostaglandin-Endoperoxide Synthases
/
Neoplasms, Squamous Cell
/
Cyclooxygenase 1
/
Cyclooxygenase 2
/
Carcinogenesis
/
Laryngeal Mucosa
/
Mouth Mucosa
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2001
Type:
Article
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