Effect of Chronical Ethanol Ingestion on the Levels of Fatty Acid Ethyl Esters (FAEEs) and Lipid Peroxidation in Rat Tissues
The Korean Journal of Nutrition
;
: 413-418, 2007.
Article
in Korean
| WPRIM
| ID: wpr-645241
ABSTRACT
The present study was designed to observe the effect of chronically ingested ethanol on the level of fatty acid ethyl esters (FAEEs), which is a non-oxidative metabolite of ethanol metabolism in tissues, and its correlation to the status of oxidative stress in rats. Forty male Sprague Dawley rats weighing 145 - 155 g were divided into 2 groups, Control and EtOH. All rats were fed Lieber-DeCarli liquid diet for 4 weeks by pair-feeding. An isocaloric maltose dextrin was added in replace of 50 g ethanol (36%kcal) in the control diet. Chronically ingested ethanol significantly increased the content of FAEEs in pancreas and liver, but not in brain. The level of 2-thiobarbituric acid reactive substances (TBARS) was significantly increased, but alpha-tocopherol level was significantly decreased in pancreas and liver. However, the levels of TBARS and alpha-tocopherol in brain were not significantly affected by ethanol ingestion. Therefore, chronically ingested ethanol might cause tissue damage by increasing the levels of FAEEs and TBARS and dissipating more alpha-tocopherol in tissues.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreas
/
Brain
/
Lipid Peroxidation
/
Control Groups
/
Thiobarbituric Acid Reactive Substances
/
Rats, Sprague-Dawley
/
Oxidative Stress
/
Alpha-Tocopherol
/
Diet
/
Ethanol
Limits:
Animals
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Nutrition
Year:
2007
Type:
Article
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