Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury
Clinical and Experimental Emergency Medicine
;
(4): 121-127, 2017.
Article
in English
| WPRIM
| ID: wpr-645332
ABSTRACT
Head injury is a common presenting complaint amongst emergency department patients. To date, there has been no widespread utilization of neuro-biomarkers to aid the diagnosis of traumatic brain injury. This review article explores which neuro-biomarkers could be used in the emergency department in aiding the clinical diagnosis of mild traumatic brain injury. Based on the available evidence, the most promising neuro-biomarkers appear to be Glial fibrillary acidic protein (GFAP) and Ubiquitin C-Terminal Hydrolase Isozyme L1 (UCH-L1) as these show significant rises in peripheral blood levels shortly after injury and these have been demonstrated to correlate with long-term clinical outcomes. Treatment strategies for minor traumatic brain injury in the emergency department setting are not well developed. The introduction of blood neuro-biomarkers could reduce unnecessary radiation exposure and provide an opportunity to improve the care of this patient group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain Concussion
/
Brain Injuries
/
Biomarkers
/
Radiation Exposure
/
Ubiquitin Thiolesterase
/
Diagnosis
/
Emergency Service, Hospital
/
Glial Fibrillary Acidic Protein
/
Craniocerebral Trauma
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Clinical and Experimental Emergency Medicine
Year:
2017
Type:
Article
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