The Effect of Topical Steroid Nasal Instillation in Induced Anosmic Mice / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1256-1260, 2004.
Article
in Korean
| WPRIM
| ID: wpr-645402
ABSTRACT
BACKGROUND AND OBJECTIVES:
The purpose of this study was to evaluate the effect of intranasal Mometasone furoate instillation into the nasal cavity of mice which had peripherally induced anosmia. SUBJECTS ANDMETHOD:
Three groups of mice were studied normal control group (nasal instillation of normal saline, n=6), Mometasone furoate non-instillation group (no treatment after nasal instillation of zinc sulfate, n=12), and Mometasone furoate instillation group (daily mometasone furoate instillation after nasal instillation of zinc sulfate, n=12). Tissues of olfactory mucosa were obtained on 1, 2, 3, 4 weeks after the instillation of zinc sulfate, and processed for immunohistochemistry using antisera to olfactory marker protein (OMP) for evaluation of olfactory regeneration.RESULTS:
No OMP-positive cells were observed in the first week after the instillation of zinc sulfate in both groups. However, OMP-positive cells began appearing in the second week in both groups and gradually increased as time goes by. In the Mometasone furoate instillation group, the increase of OMP-positive cells was significantly greater than that of Mometasone furoate non-instillation group.CONCLUSION:
Mometasone furoate instillation enhances regeneration of olfactory receptor cells after injury. Mometasone furoate instillation can be suggested as an effective treatment modality for olfactory dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Smell
/
Immunohistochemistry
/
Olfactory Mucosa
/
Olfactory Receptor Neurons
/
Zinc Sulfate
/
Olfactory Marker Protein
/
Mometasone Furoate
/
Immune Sera
/
Olfaction Disorders
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2004
Type:
Article
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