Therapeutic Effect of Zinc and Lipoprostaglandin E1 for Idiopathic Sudden Hearing Loss / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 318-323, 2015.
Article
in Korean
| WPRIM
| ID: wpr-645463
ABSTRACT
BACKGROUND AND OBJECTIVES:
We aimed to analyze the therapeutic effect of zinc, lipoprostaglandin E1 in addition to systemic steroid therapy on hearing improvement for the treatment of idiopathic sudden hearing loss. SUBJECTS ANDMETHOD:
Retrospective medical chart reviews of 500 patients who had been diagnosed with unilateral idiopathic sudden hearing loss between May 2006 and April 2014 were performed. Then, we conducted a multiple linear regression analysis using the data of individual patients.RESULTS:
Better hearing gain was associated with low tone hearing loss (p<0.001), better initial contralateral hearing (p<0.001), and the absence of dizziness (p=0.015). Patients who underwent intratympanic steroid treatment as salvage treatment showed a lower hearing gain (p<0.001). Zinc supplementation was effective for the treatment of patients with mild hearing loss (p<0.001). On the contrary, significant improvements in hearing gain were found in patients with profound hearing loss who were treated with an additional lipoprostaglandin E1 (p<0.001).CONCLUSION:
An additional use of zinc and lipoprostaglandin E1 may enhance hearing improvement for the treatment of idiopathic sudden hearing loss.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Zinc
/
Linear Models
/
Retrospective Studies
/
Hearing Loss, Sudden
/
Dizziness
/
Hearing
/
Hearing Loss
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2015
Type:
Article
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