Expression Patterns of Erythropoietin and Erythropoietin Receptor in the Spiral Ganglion of Guinea Pig after Noise Exposure / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 16-21, 2008.
Article
in Korean
| WPRIM
| ID: wpr-645525
ABSTRACT
BACKGROUND AND OBJECTIVES:
Erythropoietin (EPO) is produced in the kidney and locally in the CNS and acts through binding to erythropoietin receptor (EPO-R). Apart from playing an essential role in erythropoiesis, recent research has shown that EPO has neurotrophic and neuroprotective functions in the CNS and found EPO and EPO-R in the inner ear. The aim of this study is to investigate distribution and expression of EPO and EPO-R in the inner ear after noise exposure. MATERIALS ANDMETHOD:
Normal guinea pigs were exposed to noise. Ten of them were sacrificed at 1 hour of the noise exposure (group B) and another 10 animals were sacrificed at day 7 (group C). Four were normal controls that were not exposed to noise (Group A). Auditory function was evaluated by ABR for 7 days. Noise-induced morphological changes of cochlea were studied by phalloidin stain. The expression of EPO and EPO-R was examined by immunofluorescence.RESULTS:
The hearing threshold shift reached a level of 40 dB SPL at 8 kHz at day 1 after noise exposure and underwent a partial recovery at day 7. Increased expression of EPO and EPO-R were observed at the level of spiral ganglion cells in the noise-exposed animals.CONCLUSION:
It is suggested that noise exposure affects the distribution and expression of EPO and EPO-R in the inner ear.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phalloidine
/
Spiral Ganglion
/
Erythropoietin
/
Guinea
/
Receptors, Erythropoietin
/
Cochlea
/
Erythropoiesis
/
Guinea Pigs
/
Hearing
/
Kidney
Limits:
Animals
Country/Region as subject:
Africa
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2008
Type:
Article
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