The Expression of p53 and PCNA in Patients with Locally Recurrent Laryngeal Cancer after Radiotherapy / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 52-55, 2004.
Article
in Korean
| WPRIM
| ID: wpr-645617
ABSTRACT
BACKGROUND AND OBJECTIVES:
The biologic changes in recurrent laryngeal cancer following radiotherapy are not fully understood. The authors investigated the expression of p53 and proliferating cell nuclear antigen (PCNA) in patients with locally recurrent laryngeal cancer after radiotherapy. MATERIALS ANDMETHODS:
The authors investigated the expression of p53 and PCNA by immunohistochemical stain in 15 patients with recurrent laryngeal cancer after radiotherapy.RESULTS:
The expression of p53 protein was significantly different between laryngeal cancer before radiotherapy (4/15, 26.7%) and recurrent laryngeal cancer after radiotherapy (8/15, 53.3%) (p<0.05). Also, PCNA index was significantly different between laryngeal cancer before radiotherapy (mean, 11.9%) and recurrent laryngeal cancer after radiotherapy (mean, 18.0%) (p<0.05).CONCLUSION:
The expressions of p53 protein and PCNA were increased more in the recurrent laryngeal cancer after radiotherapy than in the laryngeal cancer before radiotherapy. Recurrent laryngeal cancers changed to biologically aggressive cancer after following radiation therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Laryngeal Neoplasms
/
Genes, p53
/
Proliferating Cell Nuclear Antigen
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2004
Type:
Article
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