Histologic Changes of Lateral Semicircular Canal after Transection and Occlusion with Various Materials in Chinchillas / 대한이비인후과학회지

ABSTRACT

BACKGROUND AND OBJECTIVES: Partial resection of vestibular labyrinth has a great interest to all otologists and neurotologists. Various materials have been applied for occlusion of semicircular canals with different postoperative hearing results. However, the most suitable material for occlusion has not determined yet. Authors tried to compare the occlusion materials through a histologic study in experimental animals. MATERIALS AND METHOD: The lateral semicircular canal (LSCC) was transected, and the canal lumens were occluded with bone dust, muscle or bone wax in chinchillas. Thresholds for the auditory brainstem response (ABR) were measured after occlusion for two months, and histologic changes of LSCC were observed. RESULTS: Periosteal osteogenesis at the surgical defects of LSCC and perilymphatic fibrosis in the canal lumen were remarkable in the bone dust and muscle groups. The bone wax group showed minimal osteoneogenesis and some degree of perilymphatic inflammation (serous labyrinthitis). CONCLUSION: This study showed complications of each occlusion material. The proper selection of an occlusion material based on its characteristics seems to be important for a successful partial labyrinthectomy.