Stimulation of bone formation in the expanding inter-premaxillary suture by vitamin E, in rat / 대한치과교정학회지
Korean Journal of Orthodontics
;
: 337-347, 2009.
Article
in English
| WPRIM
| ID: wpr-646721
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the effects of vitamin E (alpha-tocopherol) administration on bone formation in response to expansion of the inter-premaxillary suture, in rats, histomorphometrically.METHODS:
Thirty 50 - 60 day old Wistar rats were separated into five equal groups (one control and four experimental). All groups were subjected to inter-premaxilla expansion with 50-gram of force. Six control animals received saline solution (Group I) and three experimental groups were treated with a single dose of alpha-tocopherol injected into the inter-premaxillary suture after one day after appliance placement (Group II 2 mg/kg; Group III 10 mg/kg; and Group IV 50 mg/kg). A further group of six animals received three injections of 10 mg/kg alpha-tocopherol, one each on days 3, 6, and 9 (Group V). Bone formation in the suture was evaluated by bone histomorphometry. Kruskal-Wallis rank and Mann-Whitney U tests were used for statistical evaluation at p<0.05 level.RESULTS:
New bone area, bone perimeter, feret's diameter and newly formed bone measurements were significantly higher in the experimental groups than the control (p<0.001). Bone architecture in alpha-tocopherol administrated groups was improved, and bone formation during the expansion period was stimulated significantly, in a dose-dependent manner.CONCLUSIONS:
The application of alpha-tocopherol during the early stages to orthopedically expanded inter-premaxillary suture areas may stimulate bone formation and shorten the retention period, in rats.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Retention, Psychology
/
Sutures
/
Vitamin E
/
Vitamins
/
Sodium Chloride
/
Rats, Wistar
/
Alpha-Tocopherol
Limits:
Animals
Language:
English
Journal:
Korean Journal of Orthodontics
Year:
2009
Type:
Article
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