Detection of hepatitis B virus DNA and sister chromatid exchange in peripheral bloods from patients with chronic hepatitis B / 대한해부학회지
Korean Journal of Anatomy
;
: 629-635, 1999.
Article
in Korean
| WPRIM
| ID: wpr-647054
ABSTRACT
In the present study author investigated 48 patients with chronic hepatitis B for the presence of peripheral blood HBV-DNA with the aid of DNA molecular techniques. HBV-DNA was detected in peripheral blood cells in 34 of 48 (70.8%) of chronic HBsAg positive patients. In order to know that the presence of HBV-DNA in peripheral blood induce more chromosomal instability in comparison with the absent, frequency of SCE was analyzed in peripheral blood. In HBV-DNA positive chronic hepatitis B patients a mean frequency of SCE was 11.5452+/-0.6944, in HBV-DNA negative patients 11.7540+/-0.7032, respectively. Both groups had significantly higher SCE frequence than that of normal control group (5.8533+/-0.437) (p<0.05). There was no significant difference between them. This study may suggest that the presence of HBV-DNA in peripheral blood of patients with chronic hepatitis B may be related to certain pathogenetic processes in HBV infection, but it may have no effect on chromosomal instability in peripheral blood.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sister Chromatid Exchange
/
Blood Cells
/
DNA
/
Hepatitis B virus
/
Hepatitis B, Chronic
/
Siblings
/
Chromosomal Instability
/
Hepatitis
/
Hepatitis B
/
Hepatitis B Surface Antigens
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Anatomy
Year:
1999
Type:
Article
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