Non-Hodgkin lymphomas recurrence in central nervous system

ABSTRACT

A retrospective study was carried out on 32 patients with non Hodgkin lymphomas (NHL) in order to evaluate incidence rate, outcome and risk factors of central nervous system (CNS) recurrence. The results showed that: 1 patient had general manifestation and local CNS symptoms, 3 patients had CNS recurrence later on. The cumulative risk of CNS recurrence in 4 years was 19%. The CNS recurrence risk was 39% in high grade NHL, occurring usually in the first 14months, 22% in moderate grade NHL, occurring usually in the first 6 years and 7% in low grade NHL with higher degree of malignancy. In multi value analysis, NHL with high and moderate grades were independent risk factors for CNS recurrence. There are no clear evidences about role of CNS prophylaxis in patients with moderate and high grade of NHL. The survival time is 1-2 months