Two Cases of Nuclear Protein in Testis Midline Carcinomas of Sinonasal Tract / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 673-677, 2017.
Article
in Korean
| WPRIM
| ID: wpr-647319
ABSTRACT
Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive tumor that is genetically characterized by chromosomal rearrangement of the NUT gene. NMC predominantly involves the midline structures of the body and the sinonasal tract is considered a preferential site. While the optimal management of NMC is unclear, more than 80% of patients will die within one year of their diagnosis despite intensive treatment. We report two cases of NMC of the sinonasal tract. Histopathologic results of the punch biopsy showed undifferentiated and poorly differentiated carcinoma. NUT immunohistochemical staining results were positive. Multimodal treatments including surgery, radiotherapy, and chemotherapy were performed. We also present a literature review to compare with the present cases. In our cases, we emphasize the importance of the early diagnosis and intensive treatment of NMC.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Testis
/
Biopsy
/
Nuclear Proteins
/
Combined Modality Therapy
/
Early Diagnosis
/
Diagnosis
/
Drug Therapy
/
Nuts
Type of study:
Diagnostic study
/
Screening study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2017
Type:
Article
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