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Role of IL-1alpha in Cisplatin-Induced Acute Renal Failure in Mice
The Korean Journal of Internal Medicine ; : 187-194, 2011.
Article in English | WPRIM | ID: wpr-64775
ABSTRACT
BACKGROUND/

AIMS:

For unknown reasons, caspase-1 -/- mice, protected against cisplatin-induced acute renal failure (ARF), are deficient in interleukin (IL)-1alpha. We thus asked whether IL-1alpha deficiency underlies the mechanism of protection against cisplatin-induced ARF in these mice.

METHODS:

Cisplatin (30 mg/kg) was injected intraperitoneally into wild-type C57BL/6 mice to produce a cisplatin-induced model of ARF. IL-1alpha was measured in control vehicle- and cisplatin-treated wild-type animals. We also examined whether IL-1alpha -/- mice were similarly protected against cisplatin-induced ARF. Additionally, infiltration of CD11b- and CD49b-positive cells, as markers of macrophages, natural killer, and natural killer T cells (pan-NK cells), was investigated in wild-type and IL-1alpha -/- mice.

RESULTS:

Compared with vehicle-treated mice, renal IL-1alpha increased in cisplatin-treated wild-type mice beginning on day 1. IL-1alpha -/- mice were shown to be protected against cisplatin-induced ARF. No significant difference in the infiltration of neutrophils or CD11b- and CD49b-positive cells were observed between wild-type and IL-1alpha -/- mice.

CONCLUSIONS:

Mice deficient in IL-1alpha are protected against cisplatin-induced ARF. The lack of IL-1alpha may explain, at least in part, the protection against cisplatin-induced ARF observed in caspase-1 -/- mice. Investigation of the protective mechanism (s) in IL-1alpha -/- mice in cisplatin-induced ARF merits further study.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Blood Urea Nitrogen / Mice, Transgenic / Killer Cells, Natural / Biomarkers / Fluorescent Antibody Technique / Cisplatin / Apoptosis / Creatinine / Neutrophil Infiltration Type of study: Prognostic study Limits: Animals Language: English Journal: The Korean Journal of Internal Medicine Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Blood Urea Nitrogen / Mice, Transgenic / Killer Cells, Natural / Biomarkers / Fluorescent Antibody Technique / Cisplatin / Apoptosis / Creatinine / Neutrophil Infiltration Type of study: Prognostic study Limits: Animals Language: English Journal: The Korean Journal of Internal Medicine Year: 2011 Type: Article