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Hyper-proliferation of Glial Tissues Following Autologous Internal Limiting Membrane Transplantation in Idiopathic Large Macular Holes
Journal of the Korean Ophthalmological Society ; : 1307-1312, 2017.
Article in Korean | WPRIM | ID: wpr-64813
ABSTRACT

PURPOSE:

To report three cases of glial hyper-proliferation after autologous internal limiting membrane (ILM) transplantation in idiopathic large macular holes. CASE

SUMMARY:

Three eyes with full thickness macular holes >500 µm underwent autologous ILM transplantation. After surgery, the macular hole was closed and foveal contour was U-shaped. Optical coherence tomography revealed long-lasting proliferation of glial cells in the fovea after the hole closure. This glial proliferation continued for 6 months, with improved visual acuity, and bump-like features of the fovea.

CONCLUSIONS:

Autologous transplantation of ILM effectively induced long-lasting proliferation of glial cells, thereby achieving the closure of large macular holes. However, an abnormality of the foveal contour may develop after the hole closure in some cases.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Retinal Perforations / Transplantation, Autologous / Visual Acuity / Neuroglia / Tomography, Optical Coherence / Autografts / Membranes Language: Korean Journal: Journal of the Korean Ophthalmological Society Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Retinal Perforations / Transplantation, Autologous / Visual Acuity / Neuroglia / Tomography, Optical Coherence / Autografts / Membranes Language: Korean Journal: Journal of the Korean Ophthalmological Society Year: 2017 Type: Article