A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL) / 대한피부과학회지
Korean Journal of Dermatology
;
: 155-157, 2010.
Article
in Korean
| WPRIM
| ID: wpr-64817
ABSTRACT
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase, which results in higher 5-FU concentrations in tumors. Mucocutaneous side effects induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, there have been no reports of fixed drug eruption associated with TEGASIL. We report here on a case of fixed drug eruption due to oral TEGASIL.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Uracil
/
Tegafur
/
Hyperpigmentation
/
Keratoderma, Palmoplantar
/
Drug Eruptions
/
Dihydrouracil Dehydrogenase (NADP)
/
Erythema
/
Fluorouracil
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2010
Type:
Article
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