A Study of Susceptibility between Allergic Rhinitis and Glutathione S-Transferase Gene Polymorphism Study in Korean / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 866-869, 2005.
Article
in Korean
| WPRIM
| ID: wpr-648453
ABSTRACT
BACKGROUND AND OBJECTIVES:
Glutathione S-transferase (GST) enzymes have an important role in preventing the build-up of reactive oxygen species. Polymorphisms in genes involved in response to oxidative stress may play a role in the susceptibility to allergic diseases in human. A common homozygous deletion(null type) polymorphism of the GST gene abolishes the antioxidative enzyme activity. We investigated whether the profile of GSTM1 and GSTT1 genotypes might be associated with the risk of allergic rhinitis. SUBJECTS ANDMETHOD:
Blood samples for genetic analysis were obtained from 287 individuals with allergic rhinitis and from 262 healthy subjects without atopic diseases. Multiplex polymerase chain reaction-based assay for GSTM1and GSTT1 was used for genotyping.RESULTS:
The null genotype was more frequent in controls and the frequencies of the genotypes of GSTM1 were statistically different between controls and patients (p0.05).CONCLUSION:
Our result suggests that the GSTM1 and GSTT1 polymorphism is not associated with the susceptibility to allergic rhinitis in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Rhinitis
/
Reactive Oxygen Species
/
Oxidative Stress
/
Genotype
/
Glutathione
/
Glutathione Transferase
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2005
Type:
Article
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