Inhibition of Allergic Response by CpG Motif Immunostimulatory Oligodeoxynucleotide in a Murine Model of Allergic Rhinitis / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 462-466, 2002.
Article
in Korean
| WPRIM
| ID: wpr-648812
ABSTRACT
BACKGROUND AND OBJECTIVES:
The classic immunotherapy has the inconvenience and the risk of anaphylaxis. Recent reports revealed that immunostimulatory DNA sequences (CpG motif, ISS-ODN) have been shown to act as strong Th1 response-inducing adjuvants and DNA based vaccination might be an effective therapeutic option for the treatment of allergic disease. In our study, we investigated whether ISS-ODN have anti-allergic effect in the mouse rhinitis model of Dermatophagoides farinae (Der f), the most common allergen in Korea. MATERIALS ANDMETHOD:
C57BL/6 mice were sensitized with crude extract of Der f extract. After injection of ISS-ODN, several parameters of allergic response were evaluated.RESULTS:
Injection with ISS-ODN suppressed itching symptom, eosinophilic infiltration into nasal mucosa and the splenic T cell proliferation after Der f allergen challenge in the murine model of allergic rhinitis. However, injection with ISS-ODN did not show a detectable Der f-specific IgE suppression.CONCLUSION:
Our findings suggested ISS-ODN have an anti-allergic effect in the allergic rhinitis model of Der f allergen. House dust mite allergy can be reduced by the injection with ISS-ODN.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
DNA
/
Immunoglobulin E
/
Base Sequence
/
Rhinitis
/
Vaccination
/
Pyroglyphidae
/
Dermatophagoides farinae
/
Cell Proliferation
/
Eosinophils
Type of study:
Prognostic study
Limits:
Animals
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2002
Type:
Article
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