Clinical Outcomes of Early Vancomycin Administration before Identification of Methicillin-resistant Staphylococcus aureus in Patients with Nosocomial Pneumonia / 대한구급학회지
The Korean Journal of Critical Care Medicine
;
: 1-6, 2007.
Article
in Korean
| WPRIM
| ID: wpr-648834
ABSTRACT
BACKGROUND:
The aim of this study is to determine the clinical outcomes of early vancomycin administration before identification of methicillin-resistant Staphylococcus aureus (MRSA) in patients with nosocomial pneumonia on a ventilator.METHODS:
We retrospectively reviewed patients with nosocomial pneumonia in a 20-bed medical ICU during a period of 2 years and 2 months. This study included 52 inpatients, who were admitted for more than 72 hr and had a new or progressive lung infiltrate plus at least two of the following three criteria for pneumonia abnormal body temperature (>38oC or 10,000/mm3 or <3,000/mm3), and purulent bronchial secretions. All of the MRSA were identified in tracheal aspirates during mechanical ventilation.RESULTS:
A total of 23 patients who received vancomycin prior to identification of MRSA exhibited a 28-day mortality rate of 60%, while 29 patients who received vancomycin after identification of MRSA showed a 28-day mortality rate of 40% (p=0.17). There was no statistically significant difference in severity index and routine laboratory findings between the two groups.CONCLUSIONS:
Early vancomycin administration before identification of MRSA does not appear to affect the mortality rate for patients with nosocomial pneumonia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Respiration, Artificial
/
Body Temperature
/
Vancomycin
/
Ventilators, Mechanical
/
Retrospective Studies
/
Mortality
/
Methicillin Resistance
/
Methicillin-Resistant Staphylococcus aureus
/
Inpatients
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
The Korean Journal of Critical Care Medicine
Year:
2007
Type:
Article
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