Oral Proton Pump Inhibitor for Treatment of Congenital Chloride Diarrhea
Neonatal Medicine
;
: 59-63, 2016.
Article
in English
| WPRIM
| ID: wpr-64999
ABSTRACT
Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease, which is characterized by electrolyte absorption defect due to impaired function of the Cl-/HCO3 - exchanger in the ileum and the colon. Its main features are profuse watery diarrhea, high fecal chloride concentration, and failure to thrive. Profuse watery diarrhea characterized by a high concentration of chloride in stools results in hypochloremia, hyponatremia, and dehydration with metabolic alkalosis. Early detection and therapeutic intervention can prevent life-threatening symptoms of CCD and growth failure. Recently, several therapies, such as proton pump inhibitors and butyrate, have been suggested for amelioration of diarrhea. Here, we report a case of CCD in a preterm male infant who was successfully treated with an oral proton pump inhibitor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protons
/
Omeprazole
/
Butyrates
/
Proton Pumps
/
Colon
/
Dehydration
/
Diarrhea
/
Absorption
/
Alkalosis
/
Failure to Thrive
Type of study:
Screening study
Limits:
Humans
/
Infant
/
Male
Language:
English
Journal:
Neonatal Medicine
Year:
2016
Type:
Article
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