Expression of TGF-alpha, p53 and PCNA in Laryngeal Dysplasia / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 861-868, 1997.
Article
in Korean
| WPRIM
| ID: wpr-650190
ABSTRACT
BACKGROUND:
Transforming growth factor(TGF-alpha) is a polypeptide which is structurally related to epidermal growth factor(EGF) and binds to the epidermal growth factor receptor(EGFR). TGF-alpha utilizes EGFR to increase the activation of tyrosine kinase to involve in signal transduction of cellular growth. TGF-alpha synthesis occurs in a variety of neoplastic cells. p53 is a tumor-suppressor gene. There is a strong corrleation between immunohistochemical p53 positivity and p53 mutations in lung and laryngeal carcinoma. PCNA is expressed by cycling cells in late G1, S and G2 phase, and may be used to indicate the degree of cellular proliferation.OBJECTIVES:
To evaluate whether TGF-alpha, p53 and PCNA can be used as an indicator to malignant transformation of dysplasia in larynx or not. MATERIALS ANDMETHODS:
The authors investigated the TGF-alpha score, p53 immunoreactivity and PCNA proliferating index by immunohistochemical staining in 30 laryngeal dysplasia from 1992 to 1995.RESULTS:
Dysplasia with malignant transformation showed values of 5.46 for TGF-alpha, 29.2 for PCNA proliferating index and 37.5 for p53 immunoreactivity. Dysplasia without malignant transformation showed values of 1.88 for TGF-alpha, 8.6 for PCNA proliferating index and 4.5 for p53 immunoreactivity.Conclusions:
The results suggest that TGF-alpha, p53 and PCNA could be an useful indicator to predict the progression of laryngeal dysplasia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein-Tyrosine Kinases
/
Signal Transduction
/
G2 Phase
/
Transforming Growth Factor alpha
/
Proliferating Cell Nuclear Antigen
/
Cell Proliferation
/
Epidermal Growth Factor
/
Larynx
/
Lung
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
1997
Type:
Article
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