Effect of Caffeic Acid Phenethyl Ester on Lipopolysaccharide-induced Murine Macrophage Activation / 대한구급학회지
The Korean Journal of Critical Care Medicine
;
: 134-138, 2011.
Article
in English
| WPRIM
| ID: wpr-650665
ABSTRACT
BACKGROUND:
Caffeic acid phenethyl ester (CAPE) is an active component of propolis and is known to have anti-inflammatory properties. This study was performed to evaluate the effects of CAPE on lipopolysaccharide (LPS)-induced murine macrophage activation.METHODS:
Raw 264.7 cells were incubated with varying concentrations of CAPE with or without LPS. The production of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta and macrophage inflammatory protein-2 (MIP-2) and activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun amino terminal kinases (JNK) and p38 were measured.RESULTS:
CAPE inhibited the production of TNF-alpha, IL-1beta and MIP-2 and attenuated phosphorylation levels of ERK1/2 and p38, but not JNK in RAW264.7 cells stimulated with LPS.CONCLUSIONS:
CAPE can attenuate LPS-induced macrophage responses and we suggest that these effects may play an important role in modulating macrophage-mediated inflammatory responses in vivo.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylethyl Alcohol
/
Phosphorylation
/
Phosphotransferases
/
Propolis
/
Caffeic Acids
/
Cytokines
/
Interleukins
/
Tumor Necrosis Factor-alpha
/
Mitogen-Activated Protein Kinases
/
Extracellular Signal-Regulated MAP Kinases
Language:
English
Journal:
The Korean Journal of Critical Care Medicine
Year:
2011
Type:
Article
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