Expression of MAGE 3 Gene Product in Squamous Cell Carcinomas of the Head and Neck / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1296-1303, 1998.
Article
in Korean
| WPRIM
| ID: wpr-651118
ABSTRACT
BACKGROUND AND OBJECTIVES:
MAGE 3 gene may constitute a potential target for cancer immunotherapy since it is expressed in a variety of cancers but not in normal tissues except the testis. In this study, expression and intracellular location of MAGE 3 gene products were investigated using squamous cell carcinomas of the head and neck. MATERIALS ANDMETHODS:
MAGE 3 protein expression was screened in 40 squamous cell carcinomas, 2 tumor lines, 20 benign diseases, and 20 normal tissues of the head and neck. Immunohistochemical staining with anti-MAGE 3 mAb 57B was conducted from fresh frozen specimens. A correlation between MAGE 3 expression and clinicopathological parameters was also evaluated.RESULTS:
MAGE 3 gene product was detected in squamous cell carcinomas (18/40, 45%) and in tumor lines (2/2, 100%), but not in benign diseases and normal tissues. MAGE 3 gene product was identified as a cytoplasmic protein of cancer cells without staining in normal epithelia and stromal tissues coexisting adjacent to cancer cells. No significant correlation between MAGE 3 expression and clinicopathological parameters including tumor cell differentiation, age, gender, primary site, tumor stage, and metastasis was drawn.CONCLUSIONS:
MAGE 3 antigen could represent a potential target for immunotherapy in head and neck squamous cell carcinomas.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Testis
/
Carcinoma, Squamous Cell
/
Cell Differentiation
/
Cytoplasm
/
Head
/
Immunotherapy
/
Neck
/
Neoplasm Metastasis
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
1998
Type:
Article
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