The Difference between Clinical and Pathophysiologic Recovery according to Recovery Periods in Experimental Maxillary Sinusitis of Rabbit / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 512-518, 2007.
Article
in Korean
| WPRIM
| ID: wpr-651232
ABSTRACT
BACKGROUND AND OBJECTIVES:
This study was designed to investigate the difference between clinical and pathophysiologic recovery by comparing the recovery periods in the rabbit sinusitis model. MATERIALS ANDMETHOD:
A synthetic sponge was inserted into the right-side nasal cavities of 15 rabbits. After 2 weeks, the maxillary sinusitis was induced and confirmed by computed tomography (CT) scan. The opacification in CT scan was graded, and the mucosa was harvested from the maxillary sinus. Ciliary beat frequency (CBF) was measured for evaluating mucosal function. Light microscopic, scanning and transmission electron microscopic (SEM & TEM) examinations were performed. Histopathologic findings in microscopic examinations were scored in a semiquantitative measure. Each examination was performed at the time of re-opening of maxillary sinus ostium, 4 weeks and 8 weeks after re-opening of maxillary sinus ostium.RESULTS:
The sinus opacification in CT scan and ciliary regeneration in SEM showed significant improvement 8 weeks after re-opening of maxillary sinus ostium. But CBF, tissue inflammation score and ciliary wave disorder were not improved significantly 8 weeks after re-opening of maxillary sinus ostium.CONCLUSION:
Clinical, functional and histopathologic recoveries from sinusitis require different periods of time. Incomplete functional and histopathologic recoveries can be the cause of relapse or recurrence of sinusitis. Therefore, close follow-up will be necessary after clinical resolution of sinusitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Porifera
/
Recurrence
/
Regeneration
/
Sinusitis
/
Tomography, X-Ray Computed
/
Maxillary Sinusitis
/
Follow-Up Studies
/
Cilia
/
Inflammation
/
Maxillary Sinus
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2007
Type:
Article
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