Preliminary Examination for Apoptosis and Cell Proliferation Related to Aging Process in the Anterior Cruciate Ligament Cells of the Human Degenerative Arthritic Knee Joint / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 320-327, 2015.
Article
in Korean
| WPRIM
| ID: wpr-651453
ABSTRACT
PURPOSE:
We investigated the association between aging-induced apoptosis and cell proliferation in the anterior cruciate ligament (ACL) of aged patients. MATERIALS ANDMETHODS:
Twenty patients with osteoarthritis who underwent total knee replacement arthroplasty were enrolled in the study. They were divided into three groups according to age group A ( or =76 years). The ACL tissue was obtained intraoperatively and subjected to terminal deoxynucleotidyl transferase dUTP nick-end labeling staining and immunohistochemistry to quantify the apoptosis and cell proliferation indices.RESULTS:
Apoptosis occurred in all groups, with the highest apoptosis index found in group C, followed by that in groups B and A. A statistically significant positive linear correlation was observed, with a 1-year increase in age resulting in an average increase of 1.49 in the apoptotic index. The lowest cell proliferation index was observed in group C, followed by that in group B and group A, with a 1-year increase in age resulting in an average decrease of 1.0 in the cell proliferation index, which was a statistically significant negative linear correlation. Consequently, a statistically significant negative correlation was confirmed between the apoptosis and cell proliferation indices, whereby an increase of 1.0 in the apoptosis index was concurrent with a decrease of 0.45 in the cell proliferation index.CONCLUSION:
Apoptosis occurred in the ACL of human knee joint. With increasing age, apoptosis increased and cell proliferation decreased.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Arthroplasty
/
Aging
/
Immunohistochemistry
/
Anterior Cruciate Ligament
/
Apoptosis
/
Arthroplasty, Replacement, Knee
/
Cell Proliferation
/
DNA Nucleotidylexotransferase
/
Knee
Limits:
Aged
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2015
Type:
Article
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