The Relationship between Expression of E-Cadherin, Clinical Staging and Differentiation in Squamous Cell Carcinomas of the Head and Neck / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 967-971, 2000.
Article
in Korean
| WPRIM
| ID: wpr-651517
ABSTRACT
BACKGROUND AND OBJECTIVES:
In recent years, much attention has been directed towards cell adhesion molecules. This study was designed to confirm the significance of E-cadhcrin as a marker for differentiation and invasiveness of squamous cell carcinomas of the head and neck. MATERIALS ANDMETHODS:
Twenty-nine patients with squamous cell carcinoma of the head and neck were used in this study. The specimens of formalin-fixed paraffin-embedded tissues were investigated by immunohistochemical analysis using monoclonal anti-E-cadherin antibody.RESULTS:
The results showed that here was a statistically significant correlation in the head and neck squamous cell carcinoma between the T and the N stage and the expression of E-cadherin (p=0.025, p=0.015). The cell differentiation was also correlated with the reduction of E-cadherin (p =0.005).CONCLUSION:
E-cadherin may be linked to progression and differentiation of the head and neck squamous cell carcinoma. E-cadherin immunostaining in the primary tumor appear to be a good marker for the invasiveness and the metastasis of tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carcinoma, Squamous Cell
/
Cadherins
/
Cell Adhesion Molecules
/
Cell Differentiation
/
Head
/
Head and Neck Neoplasms
/
Neck
/
Neoplasm Metastasis
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2000
Type:
Article
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