The Effect of Superior Cervical Ganglionectomy on Recovery of Olfaction in Induced Anosmic Mice / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1462-1467, 2005.
Article
in Korean
| WPRIM
| ID: wpr-651625
ABSTRACT
BACKGROUND AND OBJECTIVES:
This study was undertaken to evaluate the effect of superior cervical ganglionectomy (SCG) on anosmia, which is peripherally induced in the mice. MATERIALS ANDMETHOD:
Three groups of mice (BCF1) were studied normal control (nasal instillation of saline, n=6); zinc sulfate group (nasal instillation of 64 mM zinc sulfate, n=25); SCG group (superior cervical ganglionectomy after nasal instillation of 64 mM zinc sulfate, n=25). Tissues of olfactory mucosa were obtained at 1, 2, 3, 4 and 7 weeks after instillation of zinc sulfate, and processed for immunohistochemistry using antisera to olfactory marker protein (OMP) to evaluate the olfactory regeneration.RESULTS:
No OMP-positive cells were observed in the first two weeks after the instillation of zinc sulfate in both zinc sulfate group and the SCG group. However, the OMP-positive cells appeared first at 3 weeks after the instillation in both groups, and gradually increased in number at 4 and 7 weeks. In the SCG group, the increase of OMP-positive cells was significantly greater than those of the zinc sulfate group. The number of OMP-positive cells in the SCG group at 7 weeks was almost similar to that of the normal control group.CONCLUSION:
SCG enhances regeneration of olfactory receptor cells at 3 weeks after injury. It was inferred from the above results that SCG has a significant effect on the regeneration of olfactory receptor cells and we suggest that SCG could be an effective treatment modality for olfactory dysfunction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Regeneration
/
Smell
/
Autonomic Nerve Block
/
Immunohistochemistry
/
Ganglionectomy
/
Olfactory Mucosa
/
Olfactory Receptor Neurons
/
Zinc Sulfate
/
Olfactory Marker Protein
/
Immune Sera
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2005
Type:
Article
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