Correlation between Bone Mineral Density and Knee Osteoarthritis / 대한정형외과학회잡지

ABSTRACT

PURPOSE: To examine the correlation between bone mineral density (BMD) and radiographic changes in knee osteoarthritis (OA). MATERIALS AND METHODS: BMD of the lumbar spine and hip was measured, using dual x-ray energy absorptiometry, in 297 Korean women who visited our clinic with knee joint pain; anteroposterior weight bearing X-ray of the knees was also taken. Radiographic OA was defined as a Kellgren-Lawrence score of >or=2. The relationship between BMD and the radiographic changes of OA was examined using correlation and multiple regression analysis. RESULTS: Mean BMD was lower in subjects with knee OA (n=136) than in non OA subjects (n=161) Mean BMD in the lumbar spine, OA group was 0.863 +/-0.154 g/cm2 and in the non OA group 0.896 +/-0.131 g/cm2, and there was no significant correlation between the BMD of the spine and radiographic knee OA (r=-0.087, p=0.134). Mean BMD in the hip, OA group was 0.610 +/-0.135 g/cm2 and in the non OA group was 0.662+/-0.105 g/cm2, and the difference between the two groups was significant (r=-0.227, p<0.001). CONCLUSION: Hip BMD and radiographic knee OA were found to be negatively correlated, although the mechanism remains unclear. This result differs from that of a western study and further study is needed.