Voice Characteristics of Adductor Spasmodic Dysphonia before and after Botulinum Toxin-A Injection / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
; : 148-153, 2011.
Article
in Ko
| WPRIM
| ID: wpr-652214
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Botulinum toxin type A (BTX-A) injection is well known for its effectiveness in the treatment of "Spasmodic dysphonia". However, studies on the efficacy of BTX-A injection have not been attempted in Korea. Therefore, this study was carried out to investigate the effects of BTX-A. SUBJECTS AND METHOD: The study examined 12 female patients with 'adductor spasmodic dysphonia'. Objective assesments included aerodynamic analysis and electoroglottography (EGG) of each patient before and after BTX-A. Subjective assessments included using the Korean-version of Voice Handicap Index-30 (KVHI-30) and a patient self-rating scale. RESULTS: Aerodynamic analysis revealed that only maximum phonation time (MPT) was significantly shortened after the injection of BTX-A (p<0.05). In the EGG, the mean frequency distribution was significantly increased, while the mean amplitude and the mean closed quotient distribution were significantly decreased (p<0.05). The KVHI-30 and patient self-rating scale scores were significantly decreased (p<0.01) as well, demonstrating the effects of BTX-A on the quality of life. CONCLUSION: Our results show the effects of BTX-A objectively by comparing voice characteristics, which were measured through EGG before and after BTX-A injection, as well as by determining aerodynamic characteristics. The subjective self-assessment on the quality of life is significant as it may serve as a clinically relevant measure. This study may be helpful in elucidating treatment efficacy of BTX-A in many ways.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Ovum
/
Phonation
/
Quality of Life
/
Self-Assessment
/
Voice
/
Botulinum Toxins
/
Treatment Outcome
/
Equidae
/
Botulinum Toxins, Type A
/
Dysphonia
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Ko
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2011
Type:
Article