Distribution of Beta-Catenin Expression in Adenoid Cystic Carcinoma of the Head and Neck / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 188-192, 2000.
Article
in Korean
| WPRIM
| ID: wpr-652523
ABSTRACT
BACKGROUND AND OBJECTIVES:
beta-catenin has functions in cell-cell adhesion with a complex of proteins that link cadherin to the cortical actin cytoskeleton and signal transduction through wnt developmental pathway. In this study, we investigated the distribution of beta-catenin in adenoid cystic carcinoma according to the histologic subtypes, perineural invasion, T classification, nodal status and stage. MATERIALS ANDMETHODS:
Each formalin-fixed paraffin-embedded surgical specimens were obtained from seventeen patients with adenoid cystic carcinoma. We performed immunohistochemical staining with beta-catenin monoclonal antibodies and compared its staining patterns with patients' clinical characteristics.RESULTS:
In tubular subtype, there were intense membranous staining pattern than other subtypes (p0.05).CONCLUSIONS:
It is suggest that there are mixed functional roles of beta-catenin in adenoid cystic carcinoma in tumor aggressiveness.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Actin Cytoskeleton
/
Immunohistochemistry
/
Signal Transduction
/
Adenoids
/
Classification
/
Carcinoma, Adenoid Cystic
/
Cytoplasm
/
Beta Catenin
/
Head
/
Antibodies, Monoclonal
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2000
Type:
Article
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