New Bone Formation Following Transplantation of Stem Cells and Nanoscale Hydroxyapatite Scaffold Materials into Rabbit Long Bone Defects / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 18-27, 2011.
Article
in Korean
| WPRIM
| ID: wpr-652667
ABSTRACT
PURPOSE:
We observed new bone formation following the transplantation of allogenic periosteum-derived stem cells and different sizes of hydroxyapatite (HA) scaffold materials into rabbit long-bone defects. MATERIALS ANDMETHODS:
Thirty-two white rabbits were grouped according to the material transplanted into their tibial bone defects group 1 (microscale HA only); group 2 (nanoscale HA only); group 3 (microscale HA plus stem cells); and group 4 (nanoscale HA plus stem cells). Viscosity was controlled by the relative amounts of HA and agar. After surgery, radiologic, microscopic, and biochemical observations were performed weekly for 8 weeks.RESULTS:
Nanoscale HA (groups 2 and 4) provided better bone formation than microscale HA (groups 1 and 3). The rabbits that had been transplanted with nanoscale HA plus stem cells (group 4) had more homogeneous bone formation during the natural repair process than the other groups.CONCLUSION:
Further study is required using nanoscale HA plus organic substance and stem cells, which are more similar to human bone structure, for better bone formation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Stem Cells
/
Viscosity
/
Durapatite
/
Transplants
/
Agar
Limits:
Animals
/
Humans
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2011
Type:
Article
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