The Utility of Serum PTH Assessment 1 Hour after Total Thyroidectomy / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 1012-1016, 2007.
Article
in Korean
| WPRIM
| ID: wpr-652680
ABSTRACT
BACKGROUND AND OBJECTIVES:
Hypocalcemia is the most frequent complication following total thyroidectomy. This prospective study examines the predictive value of parathyroid hormone (PTH) levels measured 1 hour after surgery. MATERIALS ANDMETHOD:
Twenty-four patients underwent total or near-total thyroidectomy for benign or malignant thyroid tumor in one year. Serum calcium and PTH levels were measured preoperatively and at 1 hour after surgery.RESULTS:
All patients were classified into three groups according to hypocalcemic symptoms and postoperative serum calcium levels. A total of 6 (25%) patients were found with hypocalcemia, as demonstrated by clinical and laboratory findings. PTH levels at 1 hour were below normal level (100%) for 6 of the 6 symptomatic hypocalcemia patients, 5 (45%) of the 11 biochemical hypocalcemia patients, and in 1 (14%) of 7 normocalcemic patients (p=0.002). The sensitivity and specificity of postoperative 1 hour PTH assessment to predict symptomatic hypocalcemia were 100% and 66%. The positive and negative predictive rate of postoperative 1 hour PTH assessment to predict symptomatic hypocalcemia were 50% and 100%.CONCLUSION:
Parathyroid gland insufficiency is the main determinant of transient hypocalcemia after bilateral thyroid surgery. Low PTH level at 1 hour after surgery is therefore a feasible predictor of postoperative symptomatic hypocalcemia and permanent hypoparathyroidism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Parathyroid Glands
/
Thyroid Gland
/
Thyroidectomy
/
Calcium
/
Prospective Studies
/
Sensitivity and Specificity
/
Hypocalcemia
/
Hypoparathyroidism
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS