Effect of Pyroligneous Liquor on Lipid Metabolism in Serum of CD Rats

ABSTRACT

This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/ Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 ( control) , PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor ( 35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride ( TG) levels were significantly decreased ( 20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased ( 20.7%, 16.3% and 20.3 %, 116.9%, respecti-vely) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased ( 63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.