A Study of Prevalence between Allergic Rhinitis and CCR5 Gene Polymorphism Study of a Korean Population / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 545-548, 2004.
Article
in Korean
| WPRIM
| ID: wpr-653649
ABSTRACT
BACKGROUND AND OBJECTIVES:
CC chemokine receptor (CCR5) is characteristic of the Th 1 phenotype, the receptor of RANTES, MIP-1alphaand MIP-1beta. The receptor of CCR5 delta32 (a 32 bp deletion in the CCR5 gene, mutant type) results in the production of a non-functional receptor. Given the potential importance of CCR5 in allergic inflammation, we hypothesized that individuals carrying the CCR5 delta32 allele would show a reduced prevalence of allergic rhinitis. SUBJECTS ANDMETHOD:
Blood samples for genetic analysis were obtained from 187 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the CCR5 gene polymorphism was used for genotyping.RESULTS:
We could not find the CCR5 delta32 homozygotes and heterozygotes at all in neither of the controls nor allergic rhinitis Korean patients.CONCLUSION:
Since the CCR5 delta32 allele frequency did not deviate from that in the healthy control population, it is unlikely that this allele influences predisposition to allergic rhinitis in Koreans.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Rhinitis
/
Prevalence
/
Chemokine CCL5
/
Receptors, CCR5
/
Asian People
/
Alleles
/
Chemokine CCL4
/
Receptors, CCR
/
Gene Frequency
Type of study:
Prevalence study
/
Risk factors
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS