Interleukin-6 Level as a Marker of Disease Activity in Rheumatoid Arthritis / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 327-331, 1999.
Article
in Korean
| WPRIM
| ID: wpr-653859
ABSTRACT
Rheumatoid arthritis (RA) is a systemic disease characterized by chronic inflammation of synovial joints accompanied by a marked acute phase response, and interleukin-6 (IL-6) is a major mediator of the inflammatory response which is involved in the induction of acute phase protein, To evaluate the significance of IL-6 levels in patients with RA, IL-6 activity was measured by radioimmunoassay in 13 patients with RA and 5 patients with traumatic arthritis (TA) or osteoarthritis (OA) was used as a control group. Serum IL-6 activity was significantly elevated in 2 RA patients without treatment compared with that of 11 RA patients with treatment and all the TA and OA patients. Synovial fluid IL-6 activity was elevated in all RA patients (markedly elevated in 2 RA patients without treatment) compared with that of TA and OA patients. Immunohistochemical analysis of synovial tissue from 3 RA patients revealed strong expression of IL-6 in most inflammatory synovial cells. The results indicate that IL-6 level, especially that of synovial fluid, is related to disease activity in patients with RA.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Arthritis
/
Arthritis, Rheumatoid
/
Synovial Fluid
/
Acute-Phase Proteins
/
Radioimmunoassay
/
Interleukin-6
/
Inflammation
/
Joints
Limits:
Humans
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
1999
Type:
Article
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