The Effect of Alpha-tocopherol Supplementation on the Improvement of Antioxidant Status and Lymphocyte DNA Damage in Postmenopausal Women
The Korean Journal of Nutrition
;
: 708-718, 2007.
Article
in Korean
| WPRIM
| ID: wpr-654037
ABSTRACT
The purpose of this project was to evaluate whether vitamin E supplementation could improve the antioxidant status and lymphocyte DNA damage in Korean postmenopausal women. This was double blinded, placebo-controlled trial. Thirty-five subject were randomized to receive either placebo 400 mg/capsule or natural alpha-tocopherol 400 IU/capsule, 2 times a day for 6 weeks. We measured plasma vitamin C, alpha-tocopherol, gamma-tocopherol, alpha-carotenoid, beta-carotenoid, lycopene concentration and tail length, %DNA in tail, tail moment in lymphocyte DNA damage index. Vitamin E supplementation group had significantly increased plasma vitamin C (p < 0.05), alpha-tocopherol (p < 0.000), whereas gamma-tocopherol (p < 0.000) and tail length (p < 0.05) were significantly decreased. However, placebo supplementation group also had significantly increased plasma vitamin C (p < 0.05). In conclusion, our study shows that vitamin E supplementation to Korean postmenopausal women may partially improve antioxidant status and lymphocyte DNA damage.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Ascorbic Acid
/
Vitamin E
/
Vitamins
/
DNA Damage
/
DNA
/
Lymphocytes
/
Alpha-Tocopherol
/
Gamma-Tocopherol
Type of study:
Controlled clinical trial
Limits:
Female
/
Humans
Language:
Korean
Journal:
The Korean Journal of Nutrition
Year:
2007
Type:
Article
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