The Effect of a High Dose of Methotrexate on Type II Collagen induced Arthritis in Rats / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 123-130, 2002.
Article
in Korean
| WPRIM
| ID: wpr-654583
ABSTRACT
PURPOSE:
Rat arthritis was induced by bovine type II collagen. To present the remedial effects on type II collagen arthritis and clinical efficacy, a high dose of methotrexate, of a level similar to that used in cancer patients was given to rats. MATERIALS ANDMETHODS:
Healthy male Brown Norway rats were used, of mean weight; 300 g. There were 7 subgroups a control group, given collagen only, an orally methotrexate treated (2.5mg/week), high methotrexate dose groups; 10 mg/kg, 30 mg/kg, 50 mg/kg, 100 mg/kg and a low dose methotrexate group (0.375 mg/kg/week, 4 times) were included in the present study. Type II collagen was injected for arthritis induction and a single intraperitoneal injection of methotrexate was administered after 15 days. Orally treated group was administered 4 times (2.5 mg/week). Histopathologic findings were evaluated.RESULTS:
50 mg/kg methotrexate was effectively reduced the arthritis index and significantly decreased inflammatory cell number between 2nd and 6 weeks.CONCLUSION:
A high dose of methotrexate may be clinically effective in the short period treatment of rheumatoid arthritis patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Arthritis, Rheumatoid
/
Cell Count
/
Methotrexate
/
Collagen
/
Collagen Type II
/
Injections, Intraperitoneal
/
Norway
Limits:
Animals
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
Korean
Journal:
The Journal of the Korean Orthopaedic Association
Year:
2002
Type:
Article
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