Clinical Evaluation and Proper Antibiotics Therapy in Office Base for the Patients Who were Infected with MRSA after ESS / 대한이비인후과학회지

ABSTRACT

BACKGROUND AND OBJECTIVES: Methicillin resistant staphylococcus aureus (MRSA) prevalence has increased over the world during past several decades and now it has become a world wide problem. It is especially more serious in domestic situations but unfortunately, until this time, there is no report about MRSA infection treatment after endoscopic sinus surgery (ESS). The objective of our study is to evaluate clinical feature of MRSA infection and to find out what kinds of treatment is the best way to control of the MRSA infection after ESS. SUBJECTS AND METHOD: The medical records of 58 patients who had the evidence that they were infected with MRSA after ESS were retrospectively reviewed. Samples were obtained by sinus endoscopy in the office base. RESULTS: Those of MRSA infected only cases were 26 cases. Co-infected cases with another microorganism were 32 cases. Forty-three cases were treated with oral rifampin alone and 11 cases were treated by a combination with oral quinolone or trimethoprim-sulfimethoxazole. Four cases failed to be treated with oral antibiotic therapy. CONCLUSION: Rifampin is the useful medication for the treatment of MRSA infected patients who had underwent ESS. Also, Rifampin is a cost effective medication compared with the glycopeptide antibiotics especially if it is used in the office base.