Role of Mast Cells in a Aspergillus Murine Model of Allergic Rhinitis / 대한이비인후과학회지
Korean Journal of Otolaryngology - Head and Neck Surgery
;
: 912-967, 2006.
Article
in Korean
| WPRIM
| ID: wpr-655329
ABSTRACT
BACKGROUND AND OBJECTIVES:
Mast cells are the main effector cells in the immediate phase of the allergic responses. To evaluate the role of mast cells on the development of allergen-induced eosinophilic inflammation in a murine model of allergic rhinitis(AR), we compared the responses of mast cell deficient (W/Wv) mice with congenial normal (W/W+) mice. MATERIALS ANDMETHOD:
Mice were sensitized intranasally with an extract of Aspergillus fumigatue (Af) for 3 weeks, and challenged intranasally with a single dose (acute model) or single dose every day for 5 consecutive days (chronic model). Interleukin (IL)-5 in nasal lavage fluids (NLF), histologic examination and Af-specific immunoglobulins (Ig) were examined in W/Wv mice and W/W+mice.RESULTS:
In the sensitized W/Wv mice, the number of eosinophils in the nasal mucosa and IL-5 in NLF after repeated allergen challenge were not significantly different from those of W/W+ mice. In contrast, the number of eosinophils in the nasal mucosa and IL-5 in NLF after single allergen challenge were partially attenuated in W/Wv mice. The levels of Af-specific IgE and IgG1 in both acute and chronic models were not different between W/Wv mice and W/W+ mice.CONCLUSION:
These findings suggest that eosinophilic inflammation caused by repeated allergen challenge are independent of mast cells in this AR model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspergillus
/
Immunoglobulin E
/
Immunoglobulin G
/
Immunoglobulins
/
Rhinitis
/
Interleukins
/
Interleukin-5
/
Nasal Lavage Fluid
/
Models, Animal
/
Eosinophils
Type of study:
Prognostic study
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Otolaryngology - Head and Neck Surgery
Year:
2006
Type:
Article
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