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Endothelial Progenitor Cells' Classification and Application in Neurological Diseases
Tissue Engineering and Regenerative Medicine ; (6): 327-332, 2017.
Article in English | WPRIM | ID: wpr-655428
ABSTRACT
The therapeutic effects of endothelial progenitor cells (EPCs) on ischemic stroke have been extensively studied in recent years. However, the differences in early EPCs and endothelial outgrowth cells (EOCs) are still unclear. Clarifications of their respective properties and specific functioning characteristics contribute to better applications of EPCs in ischemic diseases. In this review, we discuss cellular origin, isolation, culture, surface markers of early EPCs and EOCs and relevant applications in neurological diseases. We conclude that EOCs possess all haracteristics of true endothelial progenitors and have potent advantages in EPC-based therapies for ischemic diseases. A number of preclinical and clinical applications of EPCs in neurological diseases are under study. More studies are needed to determine the specific characteristics of EPCs and the relevant mechanisms of EPCs for neurological diseases.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Classification / Stroke / Therapeutic Uses / Endothelial Progenitor Cells Language: English Journal: Tissue Engineering and Regenerative Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Classification / Stroke / Therapeutic Uses / Endothelial Progenitor Cells Language: English Journal: Tissue Engineering and Regenerative Medicine Year: 2017 Type: Article